Dogs have long been reported to have a higher concentration of CB1 receptors in certain areas of the brain (particularly the brain stem and cerebellum) than people. Newer studies that have examined the distribution of CB1 receptors in the canine brain, however, have not supported this theory. Nonetheless, they do appear to be more susceptible to the effects of CB1 ligands such as THC. As with many medications, “the poison is in the dose”, and new studies are looking at the potential therapeutic benefits of using THC in animals, including dogs. Previous studies have shown that the minimum dose typically required to produce signs of toxicity in dogs, is 0.5mg/kg administered intravenously, however differences in routes of administration, individual variances, and adaptation, can make knowing the exact dose to avoid difficult.